Adipotide is a peptidomimetic compound that has been shown to possess pro-apoptotic properties that do cause weight loss in rhesus monkeys and mice. Its sequence is CKGGRAKDC-GG-D(KLAKLAK)2. Studies have shown that its mode of action involves the selective apoptosis of blood vessels supplying the white adipose tissue. Adipotide causes such vessels to undergo atrophy (shrinkage) and eventually apoptosis (cell death), thus cutting off the blood supply to the fat cells. This results in ischemic injury, which is a lack of blood supply and oxygen to the fat cells. The effects are non-reversible, so the fat cells also undergo apoptosis or cell death.
April 14, 2026